{"id":27927,"date":"2025-05-30T12:00:35","date_gmt":"2025-05-30T17:00:35","guid":{"rendered":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/?p=27927"},"modified":"2025-05-15T13:12:24","modified_gmt":"2025-05-15T18:12:24","slug":"oral-care-probiotics-and-periodontal-health-a-clinical-case-study","status":"publish","type":"post","link":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/2025\/05\/30\/oral-care-probiotics-and-periodontal-health-a-clinical-case-study\/","title":{"rendered":"Oral Care Probiotics and Periodontal Health: A Clinical Case Study"},"content":{"rendered":"<p><a href=\"https:\/\/probiorahealth.com\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27929\" src=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/02-logo-tag-color-copy.png\" alt=\"\" width=\"707\" height=\"136\" srcset=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/02-logo-tag-color-copy.png 613w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/02-logo-tag-color-copy-300x58.png 300w\" sizes=\"(max-width: 707px) 100vw, 707px\" \/><\/a><\/p>\n<h3><b>How ProBiora Probiotics Turned Around a Severe Periodontal Case<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Periodontal disease can be notoriously difficult to treat, especially when it persists despite traditional and advanced therapies. This case study highlights how oral care probiotics, specifically ProBiora products, helped resolve a severe periodontal condition when other traditional methods failed.<\/span><\/p>\n<h3><b>Patient Background<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">A 52-year-old patient presented with a history of moderate to severe chronic periodontitis. Symptoms included bleeding on probing (BOP), generalized 4-6 mm pocket depths, gum tenderness, and persistent inflammation. The patient had undergone repeated scaling and root planing, laser assisted periodontal therapy (LAPT), and laser bacterial reduction (LBR) with limited success. Bleeding remained widespread, and deep periodontal pockets persisted. Frustrated by the lack of progress, the patient was open to exploring alternative therapies. A saliva test for periodontal pathogens was also conducted, pre-therapy, to track treatment progress, which showed elevated levels of Pg, Td, Tf, and Fn.<\/span><\/p>\n<h3><b>The Intervention: ProBiora Probiotics<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Given the stubborn nature of her disease, the patient was placed on a daily regimen of ProBiora Professional Strength, an oral care probiotic containing ProBiora3\u00ae, a patented blend of three probiotic strains: <\/span><i><span style=\"font-weight: 400;\">Streptococcus oralis<\/span><\/i><span style=\"font-weight: 400;\"> KJ3, <\/span><i><span style=\"font-weight: 400;\">Streptococcus uberis<\/span><\/i><span style=\"font-weight: 400;\"> KJ2, and <\/span><i><span style=\"font-weight: 400;\">Streptococcus rattus<\/span><\/i><span style=\"font-weight: 400;\"> JH145. The goal was to repopulate the oral cavity with beneficial bacteria capable of inhibiting the growth and outcompeting pathogenic species associated with periodontal disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The patient was instructed to dissolve one ProBiora Professional Strength tablet in her mouth nightly after brushing and flossing while maintaining her existing hygiene practices and periodontal maintenance schedule.<\/span><\/p>\n<h3><b>Results<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">After 12 months of ProBiora Professional Strength use, the results were significant:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding on probing was reduced by 100%.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Most 4-6 mm pockets were reduced to 2-3 mm.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gingival tissues appeared pink, stippled, and far less inflamed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Periodontal pathogens present in saliva decreased substantially with decreases of 1-3 logs after ProBiora use (Figure 1).<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Periodontal charting confirmed substantial improvements (Figure 2A-B). Previously critical sites stabilized, and surgical intervention was no longer indicated.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27932\" src=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora.png\" alt=\"\" width=\"833\" height=\"344\" srcset=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora.png 2475w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora-300x124.png 300w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora-1024x423.png 1024w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora-768x317.png 768w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora-1536x634.png 1536w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-1-ProBiora-2048x846.png 2048w\" sizes=\"(max-width: 833px) 100vw, 833px\" \/><br \/>\n<b>Figure 1.<\/b><span style=\"font-weight: 400;\"> Genome copies of periodontal pathogens in saliva samples after multiple interventions (scaling and root planing, LAPT, LBR, CloSYS) but prior to ProBiora probiotic use (grey bars) and after 12 months of ProBiora oral care probiotic use.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27930 \" src=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2-ProBiora-e1747233745894.png\" alt=\"\" width=\"389\" height=\"285\" srcset=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2-ProBiora-e1747233745894.png 491w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2-ProBiora-e1747233745894-300x220.png 300w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2-ProBiora-e1747233745894-135x100.png 135w\" sizes=\"(max-width: 389px) 100vw, 389px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27931 \" src=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2.5-ProBiora-e1747233777913.png\" alt=\"\" width=\"347\" height=\"284\" srcset=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2.5-ProBiora-e1747233777913.png 440w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/Figure-2.5-ProBiora-e1747233777913-300x245.png 300w\" sizes=\"(max-width: 347px) 100vw, 347px\" \/><br \/>\n<b>Figure 2. <\/b><span style=\"font-weight: 400;\">A: Periodontal health following multiple interventions (scaling and root planing, LAPT, LBR, CloSYS) but prior to ProBiora probiotic use; B: Periodontal health following 12 months of ProBiora probiotic use.<\/span><\/p>\n<h3><b>Discussion<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">This case highlights the potential of oral care probiotics as a valuable adjunct to periodontal therapy. While traditional treatments focus on mechanical debridement, they do not directly address the imbalance of the oral microbiome. ProBiora probiotics introduce beneficial bacteria native to the teeth and gums that suppress harmful oral pathogens, promoting an environment conducive to healing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although larger-scale studies are still ongoing, cases like this suggest that oral care probiotics can offer substantial clinical benefits, particularly for patients with refractory periodontal disease. They represent a non-invasive, safe, and easily integrated addition to traditional oral care.<\/span><\/p>\n<h3><b>Conclusion<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">For this patient, oral care probiotics provided the missing link; their use is supported by both traditional periodontal measurements and salivary diagnostic testing. After years of failed treatments, the patient finally achieved lasting improvements in gum health, pocket depth reduction, and lower periodontal pathogen loads. This case reinforces the growing evidence that a balanced oral microbiome is critical for periodontal stability \u2014 and that ProBiora Professional Strength oral care probiotics can make that balance achievable.<\/span><\/p>\n<p><a href=\"https:\/\/www.oraldna.com\/get-started\/\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-25260 alignnone\" src=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2024\/08\/joinoraldna.png\" alt=\"Join OralDNA\" width=\"774\" height=\"221\" srcset=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2024\/08\/joinoraldna.png 1404w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2024\/08\/joinoraldna-300x86.png 300w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2024\/08\/joinoraldna-1024x292.png 1024w, https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2024\/08\/joinoraldna-768x219.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>How ProBiora Probiotics Turned Around a Severe Periodontal Case Periodontal disease can be notoriously difficult to treat, especially when it persists despite traditional and advanced therapies. This case study highlights how oral care probiotics, specifically ProBiora products, helped resolve a severe periodontal condition when other traditional methods failed. Patient Background A 52-year-old patient presented with <a class=\"read-more\" href=\"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/2025\/05\/30\/oral-care-probiotics-and-periodontal-health-a-clinical-case-study\/\">Read More<\/a><\/p>\n","protected":false},"author":216,"featured_media":27929,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[60,10,143,110],"tags":[61,78,16,206,112,51,76,145],"class_list":["post-27927","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","category-periodontal-disease","category-probiotics","category-salivary-diagnostics","tag-case-study","tag-clinical-lab-testing","tag-dental-test-for-bacteria-in-the-mouth","tag-oral-probiotic","tag-patient-education","tag-perio-disease","tag-periodontal-disease","tag-probiotics"],"jetpack_featured_media_url":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/wp-content\/uploads\/2025\/05\/02-logo-tag-color-copy.png","jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p7W16z-7gr","_links":{"self":[{"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/posts\/27927"}],"collection":[{"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/users\/216"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/comments?post=27927"}],"version-history":[{"count":4,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/posts\/27927\/revisions"}],"predecessor-version":[{"id":27941,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/posts\/27927\/revisions\/27941"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/media\/27929"}],"wp:attachment":[{"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/media?parent=27927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/categories?post=27927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.oraldna.com\/trends-in-salivary-testing\/index.php\/wp-json\/wp\/v2\/tags?post=27927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}