Reference Lines<\/a> help the clinician align\/confirm their assessment of the severity of the clinical signs (BOP, pocket depth, radiographic evidence of bone loss, attachment loss) with the quantity of bacteria typically measured with those clinical features. The definition of the MyPerioPath reference lines takes into consideration patient results representing varying backgrounds\/situations and it is the mean quantity of each of the 11 bacteria present in patients with (clinically observable) chronic periodontitis. The Reference Lines represent a midpoint of the amount of bacteria correlated with a certain severity of clinical disease. The statistical power of these analyses is extraordinary and reliable.<\/span><\/p>\nOther Risk Factors and the Patient\u2019s Personal Tipping Point: <\/b>Deciding who and how to treat is ultimately based on clinical findings and determined by the treating healthcare professional.\u00a0 The Reference Lines displayed on each result report should be a guidepost to ask \u201cWhat other parts of this patient’s health might raise or lower the black lines, reflecting their personal tipping point?\u201d Diabetes is one obvious systemic risk factor that is likely to decrease the patient\u2019s personal tipping point. Smoking is another. In both cases there is the altering of the person\u2019s immune function that gives rise to the clinical signs of inflammation and chronic effects of tissue damage with lesser levels of these key pathogens. Genetic susceptibility manifests greater than needed levels of chronic inflammation, also possibly lowering the patient\u2019s personal tipping point. There are several genetic salivary tests for the clinician to consider for objective and concrete information regarding a patient\u2019s genetic risk, such as MyPerioID\u00ae IL-6 (part of Alert 2\u2122) and Celsus One\u2122. This is a limited list of other risk factors that may impact the patient\u2019s personal tipping point. For this reason, a complete review of the medical history with each patient is always the standard of care, and critical to uncover other important risk factors.<\/span><\/p>\nThe Systemic Antibiotic Selection: <\/b>The Reference Lines are not the basis by which a clinician should choose to use an antibiotic. Rather, the black lines on each MyPerioPath\u00ae report serve as an indicator of a consensus regimen for the selection of which antibiotic to prescribe. When there is a single bacteria, or combination of bacteria, above the reference line, an antibiotic(s) selection will be inserted in the Treatment Suggestions section of the report (if you select to have the option displayed upon ordering). If the bacteria are present but below the reference line, a resource called MyPerioPath\u00ae Antibiotic Options, is available for the clinician to determine the most appropriate antibiotic option(s).<\/span><\/p>\nAlternative to Reference Lines: <\/b>Some clinicians prefer to base treatment options on total bacterial load rather than Reference Lines. In these cases, there is an option when ordering the MyPerioPath\u00ae or Alert 2\u2122 to have the Reference Lines removed from the lab report. If the option for removal is selected, the systemic antibiotic option is still based off of the Reference Lines, and an antibiotic selection will appear only when levels exceed the threshold.<\/span><\/p>\n
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