“Biohacking” Our Genes Using Celsus One™ and Nrf2 Activation

In my practice, I am a “biohacker,” helping my patients become healthy at the cellular level, using biomarkers, saliva tests, blood work, and new-age supplements; hacking the genetic code to help my patients live a preventive lifestyle. I often tell my patients that their mouth is an indication of their internal body tissue health. Incorporating the genetic analysis from the Celsus One™ report helps me establish personalized health recommendations utilizing genetic risk factors related to the oral and systemic inflammatory response.

Utilizing genetics in conjunction with products that activate NRF1 (Nuclear respiratory factor 1) and Nrf2 (nuclear factor erythroid 2 (NFE2)-related factor 2) pathways to create internal cellular molecules can turn back the aging process and become part of a full preventive program. Considering that there are over 200 disease processes that start with inflammation, it’s exciting that Celsus One™ shows 8 biomarkers associated with periodontal, diabetes, cardiovascular and arthritis.

Since the lab results show the patient’s own unique genetic makeup, health providers can educate patients on how the genotypes of certain gene markers affect their long-term systemic health. The three innate gene markers: Beta-defensin 1 (DEFB1), CD14 (CD14), and Toll-like receptor 4 (TLR4), and five acquired gene markers: Tumor necrosis factor-alpha (TNF-alpha) Interleukin 1 (IL1), Interleukin 6 (IL6) Interleukin 17A (IL17A) Matrix Metallopeptidase 3 (MMP3) have different variations in degree of severity in association with inflammatory disease processes. The variation for personalizing patient care helps me to decide on periodontal therapy adjuncts, frequency of periodontal recare, environmental challenges, and ultimately how to best educate my patients in being proactive. My patient’s feel empowered knowing they can potentially influence the effect of their genetics.

Protandim®, Nrf2 Activator™, has 5 patents with over 25 independent peer reviews found on www.pubmed.gov, and is one of my favorite product lines that I have incorporated into my practice. (Previously written: It works at the cellular level to activate ATP and mitochondria, and has been clinically proven to reduce oxidative damage by 40% within 30 days). Correction: Protandim Nrf1 activator increases ATP and Mitochondria function and Nrf2 activation reduces oxidative stress by 40% within 30 days. Oxidative stress (free radical damage) is a root cause of all disease processes. Nrf2 is a protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. The Nrf2 protein remains dormant within each cell of our body, unable to move or perform its task until released by an Nrf2 activator.

The Nrf2 genetic pathway turns on over 400 transcription genes such as GSTP1, which is related to detoxification. Prior to the Protandim® product line, Sulforaphane, found in broccoli sprouts, was the “gold” standard of naturally occurring Nrf2 activators. Studies have shown that Protandim® Nrf2 Activator™ is 135 fold more powerful than Sulforaphane. Protandim® Nrf2 is composed of 5 herbs that each in their own right have an ayurvedic effect, but also have been proven to work better together synergistically rather than each component individually. A second activator, Protandim® NRF1, works as a “One-Two Punch,” increasing ATP, mitochondrial DNA transcription, replication activity, and quality of sleep.

I am successfully helping my patients utilize their personalized Celsus One™ results to biohack their genetics, using proven modern tools such as Nrf1 and Nrf2 activators to improve their environments. Reducing systemic inflammation using the most modern science and supplements helps me stay on the cutting edge and I am definitely a BIOHACKER for life.

To find out more about this topic please go to http://www.synergydentalgroup.net/ and contact Dr. Kimberly Hubenette.
**To learn more about becoming an OralDNA Provider: Text “OralDNA” to 31996**


Kimberly Hubenette DDS MAGD

Kimberly Hubenette DDS MAGD

Kimberly Q. Hubenette, DDS, MAGD is the owner of Synergy Dental Group, a private practice in Sonoma.She is an entrepreneur and innovator in Anti-Aging Dentistry.A graduate from the University of Southern California Dental School, she is dedicated to constant and never ending improvement with career, staff, and life. She is a Master of Academy of General Dentistry, a Fellow in International Congress of Oral Implantology and a Fellow of the Academy of Craniofacial Facial Pain. Dedicated to life-long learning, her current accomplishments include volunteering at UCSD Free Dental Clinic,teaching as a clinical professor at UCSF and UOP and. serving as Past President of San Diego AGD and past Board member of California AGD.

Dr. Hubenette is a leader in business, a trainer and mentor to dentists, assistants, hygienists, students and the public.Addressing topics such as implementation of natural alternatives in every day dental services, The Whole Body Effect and training dentists to become the liaison between medical and dental health practitioners to create a health centered dental practice all dentists can implement.

Patients are now intelligent shoppers, Internet users and are pursuing alternative health care alternatives. They are buying into better health with the new medical model of dentistry for whole body health.

Dr. Hubenette serves as a coach to other dental professionals, both on a local and national level, teaching leadership, natural alternatives and efficiency of business. She also shares her personal experience and knowledge regarding health care alternatives utilizing Nrf2 technology.

The new generation of patients are becoming more intelligent ,consumers demanding more explanations.It is to your advantage to understand, diagnose and educate Complete Whole Body Dental Care. Implement an easy system, train your staff, and educate your patients

The Value lies not simply in increased production, but in how you feel when you've helped someone with their health.

Kimberly Hubenette DDS MAGD

Latest posts by Kimberly Hubenette DDS MAGD (see all)

5 thoughts on ““Biohacking” Our Genes Using Celsus One™ and Nrf2 Activation

  1. The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners

  2. Correction:Protandim Nrf1 activator increases ATP and Mitochondria function and Nrf2 activation reduces oxidative stress by 40%within 30 days.

  3. 27 peer review studies that reference Protandim
    From Dr. Nathalie Chevreau Sr VP of Research & Development
    OFFICE 801.432.9240
    LifeVantage.com 9785 S. Monroe Street – Suite 300, Sandy, UT 84070

    Human studies (5)
    1. Nelson (2005)—Healthy humans (120 days)
    Nelson, C. G. (2005). Photoprotection. Sunscreens – Regulations and Commercial Development. N. Shaath. New York, Taylor & Francis: 19-43
    2. Burnham (2012)—Humans with alcohol use disorders (1 week)
    Burnham, E. L., et al. (2012). “Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.” Am J Physiol Lung Cell Mol Physiol 302(7): L688-699.
    3. Scalzo (2014)—Healthy Overweight humans & JP Protandim (30 days)
    Scalzo, R. L., et al. (2014). Oxidative stress is decreased with short term Protandim use when piperine is substituted for ashwagandha. Experimental Biology, San Diego.
    4. Ueberschlag (2016) – Runners (90 days)
    Ueberschlag, S. L., et al. (2016). The effect of Protandim supplementation on athletic performance and oxidative blood markers in runners. PLoS One DOI:10.1371: 1-26
    5. Konopka (2017) Influence of Nrf2 activators on subcellular skeletal muscle protein
    Konopka, A. R., et al. (2017). “Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults.” Geroscience.

    Laboratory studies (15)
    1. Velmurugan (2009)—Mice MIN6 pancreatic beta-cells
    Velmurugan, K., et al. (2009). “Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.” Free Radic Biol Med 46(3): 430-440.
    2. Liu (2009)—Mice with skin cancer
    Liu, J., et al. (2009). “Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.” PLoS One 4(4): e5284.
    3. Bogaard (2009)—Rats heart muscles cells
    Bogaard, H. J., et al. (2009). “Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.” Circulation 120(20): 1951-1960.
    4. Robbins (2010)—Mice with skin cancer
    Robbins, D., et al. (2010). The chemopreventive effects of Protandim: Modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. PLoS One 5(7): e11902.
    5. Qureshi (2010)—Mice with muscular dystrophy
    Qureshi, M. M., et al. (2010). “The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice.” J Diet Suppl 7(2): 159-178.
    6. Joddar (2011)—Human saphenous veins.
    Joddar, B., et al. (2011) Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway. Free Radic Biol Med 50(2011): 700-709.
    7. Donovan (2012) Phytochemical Activation of Nrf2
    Donovan, E. L., et al. (2012). “Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge.” Oxid Med Cell Longev 2012: 132931.
    8. Dugan (2012)—Breast cancer cells
    Dugan, A., et al. (2012). “Comparison of the dietary supplement Protandim and 4-hydroxytamoxifen on pre-malignant human breast cancer cells.” The FASEB 26.
    9. Reuland (2013)— Heart muscle cells
    Reuland, D. J., et al. (2013). “Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress.” Free Radic Biol Med 56: 102-111.
    10. Lisk (2013)—Rats & acute mountain sickness
    Lisk, C., et al. (2013). “Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.” Free Radic Biol Med 63: 264-273.
    11. Strong (2016) – Mice and longevity
    Strong, R. (2016). “Nrf2 and longer lifespan in mice treated with Protandim ” Aging Cell: 12496
    12. Abusarah (2016) – Human & mice cartilage cells
    Abusarah, J., et al., (2016) Elucidating the role of Protandim and 6-gingerol in protection against osteoarthritis. Cell Biochemistry [10.1002/jcb.25659]
    13. Lim (2016) – Rat brain cells (oligodendrocytes)
    Lim, J. L., et al. (2016). “Protandim Protects Oligodendrocytes against an Oxidative Insult.” Antioxidants (Basel) 5(3).
    14. Chevreau (2017) – Primary human small intestinal epithelial cells (Extended Abstract)
    Chevreau, N., (2017) Protandim treatment causes reversible nuclear translocation of Nrf2 and activation of the antioxidant response element. JISANH 3(3):11865.
    15.Priestley(2019)-Rats and Hamsters
    Priestley, JRC, et al.(2019) NRF2 Activation with Protandim Attenuates Salt-Induced Vascular Dysfunction and Microvascular Rarefaction.Nrf2 activation Protects against salt-induced vascular dysfunction by restoring redox homeostasis in the vasculature. MICROCIRCULATION:e12575


    Scientific Reviews (7)
    1.Robbins (2011)—MnSOD and skin cancer
    Robbins, D., et al. (2011). The role of manganese superoxide dismutase in skin cancer. SAGE-Hindawi Enzyme Research 2011, 409295: 1-7
    2. Hybertson (2011)—Potential of Nrf2 activation.
    Hybertson, B. M., et al. (2011). “Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.” Mol Aspects Med 32(4-6): 234-246.
    3. Davis (2012)—Antioxidants and oral care
    Davis, K. (2012). “Understanding Antioxidants_ Using Various Arsenals to Impact the Oral Environment.” Dental Today.
    4. Voelkel (2013)—Pulmonary artery hypertension
    Voelkel, N. F., et al., (2012).Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension?. Antioxidants & Redox Signaling DOI: 10.1089/ars.2012.4828
    5. Reuland (2013)—Attenuation of cardiovascular disease
    Reuland, D. J., et al. (2013). “The role of Nrf2 in the attenuation of cardiovascular disease.” Exerc Sport Sci Rev 41(3): 162-168.
    6. Gao (2014)—The clinical potential of Nrf2 activation
    Gao, B., et al. (2014). “The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders.” Clin Pharmacol 6: 19-34.
    7. Pall (2015)- Nrf2 a master regulator
    Pall, M. L. and S. Levine (2015). “Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors.” Sheng Li Xue Bao 67(1): 1-18.

  4. Thank your for this informative article! I was wondering, do you recommendations for supplementation vary depending on the test results? If so, how can I find more information on the subject?
    Thank you!

  5. Kimberly Hubenette says:

    Robbie, Yes my recommendations vary according to the test results. With the COVID 19 Pandemic occurring, I highly recommend advocating to patients to boost their immune systems with these activators. For more science please refer to
    https://www.biohackandactivate.com/ and you may contact me

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