A nice, friendly smile is visually attractive and is also a sign of good oral hygiene practice and cognitive health. Numerous studies have found a close connection between poor oral hygiene and dementia. Studies have found that those with poor oral hygiene practices are at higher risk for dementia, and dementia patients are at higher risk for developing gum disease. Poor oral hygiene and inadequate nutrition are likely the primary drivers for the risk of gum disease in dementia patients, particularly as the disease progresses. A meta-analysis of 14 studies involving over 30,000 participants found that poor oral hygiene was associated with an approximately 1.5 times higher risk for cognitive impairment. Inflammation is thought to be the primary mechanism by which gum disease increases the risk for cognitive decline.
The oral cavity, which has a close nexus with the brain, is home to hundreds of species of bacteria. While most are harmless, a few types (e.g. P. gingivalis) can promote gum disease. Patients with Alzheimer’s disease (AD) are more likely to have higher levels of harmful gum disease-related bacteria. The presence of the bacteria in the gums also triggers an immune response, and an uncontrolled immune response can lead to chronic inflammation of the gums, called gingivitis. If left untreated, the bacteria continue to accumulate, leading to a more serious chronic infection called periodontitis. Studies in lab animals have shown that both the bacteria and the inflammatory molecules can make their way from the mouth to the blood and into the brain. Once in the brain, bacteria release enzymes called gingipains that can destroy nerve cells, which in turn can lead to memory loss.
Bacteria associated with gum disease, such as P. gingivalis, have also been found in the brains of AD patients. In one study, researchers examined the brains of 53 deceased people who had suffered from Alzheimer’s and found high levels of gingipains in almost all of them. They also noted that the concentration of gingipains increased over time, suggesting that there may be a threshold when dementia symptoms first begin. The presence of the bacteria in the brain promotes inflammation and triggers brain pathology associated with AD.
Furthermore, oral bacteria associated systemic inflammation is linked to diabetes and cardiovascular disease, which in turn are risk factors for dementia. Thus, inflammation due to poor oral hygiene practices may be a common mechanism linking these risk factors. Additionally, an improper diet also increases the risk for all of these conditions. A diet rich in processed foods that contain lots of easily digestible sugars can promote the growth of the disease-causing bacteria in the mouth. Eating too much sugar and highly processed food leads to metabolic changes that promote inflammation and makes the immune system more vulnerable to infections, thus putting the individual in an endless loop of persistent infection and inflammation due to faulty dietary choices and poor oral hygiene practices.
Good oral hygiene is multi-faceted. It involves routine dental care, diet, and management of chronic diseases. While some medications can trigger dryness in the mouth, soda, fermented juices, and many foods can create an acidic environment in the oral cavity. Acidic foods/fluids and a dry mouth fuel the growth of the pathogenic bugs. If you have a dry mouth, talk to your doctor about your medications and find out if adjustments can be made. Patients that have AD typically experience worsening oral health as their condition progresses. In the earlier stages of the disease, patients can often continue their daily routines — including brushing their teeth and maintaining their regular visits to the dentist. As their condition worsens and their cognitive function decreases, AD patients tend to forget these routines, which can have detrimental effects on their oral health and overall wellbeing.
Prevention is vital when it comes to caring for someone with Alzheimer’s. Diets rich in non-starchy vegetables and some resistant starches are recommended to avoid inflammation triggered by oral bacteria. Prioritize vegetables that are below 35 on the glycemic index and choose organic, seasonal fruits with a low glycemic index to promote the growth of healthy bacteria. Probiotics for oral health such as S. salivarius can help to reduce pathogenic bacteria. Just as there are benefits to optimizing your gut microbiome, there are also benefits to optimizing your oral microbiome. Remember, the road to good cognitive health begins in the mouth. Protect your brain by taking care of your mouth, gums, and teeth with good oral hygiene practices.
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References:
- Sadrameli, M.; Bathini P.; Alberi L. Linking mechanisms of periodontitis to Alzheimer’s disease. Curr Opin Neurol. 2020,33,230-238.
- Beydoun, M.A.; Beydoun H.A.; Hossain S.; El-Hajj Z.W.; Weiss J.; Zonderman A.B. Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer’s Disease Dementia in a Large National Survey. J Alzheimers Dis. 2020,75,157-172.
- Mao, S.; Huang C.P.; Lan H.; Lau H.G.; Chiang C.P.; Chen Y.W. Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review. J Dent Sci. 2022,17,1762-1779.
- Poor oral health conditions and cognitive decline: Studies in humans and rats. Zhang et al. PLOS ONE, 15(7), 2020
- Beydoun M, et al. Clinical and bacterial markers of periodontitis and their association with incident all-cause and Alzheimer’s disease dementia in a large national survey. Journal of Alzheimer’s Disease. 2020;75(1):157-172. doi: 10.3233/JAD-200064.
- Oral Hygiene and Cognition By: Ram Rao, PhD - November 11, 2022