Periodontal Inflammation Primes the Systemic Innate Immune Response

Posted on November 20, 2020November 19, 2020 by Ronald C. McGlennen, MD

This week, Dr. Ronald McGlennen - President & Medical Director of OralDNA® Labs provides a review of the recently published article "Periodontal Inflammation Primes the Systemic Innate Immune Response” written by N. Fine, J.W. Chadwick, C. Sun, K.K. Parbhaker, N. Khoury, A. Barbour, M. Golberg, H.C. Tenebaum, and M. Glogauer. This article appears in the Journal of Dental Research, October 2020. The complete article can be accessed here. Enjoy the VLOG and please feel free to share any...

OralDNA has FDA EUA for Saline, Swish & Gargle Only Collection

Posted on October 9, 2020October 7, 2020 by Ronald C. McGlennen, MD

Sept. 30, 2020 /PRNewswire/ -- Access Genetics, LLC dba OralDNA® Labs announces that FDA has issued an amended Emergency Use Authorization for the OraRisk® COVID-19 RT-PCR test allowing testing from a saline oral rinse collection. This is the first Emergency Use Authorization for a simple saline 30 second swish and gargle collection. It eliminates the need for a nasal swab and avoids the difficulty some individuals have in providing sufficient saliva for saliva direct testing. Samples are vi...

COVID-19: A Primer for the Dental Professional, Part 2

Posted on June 5, 2020June 4, 2020 by Ronald C. McGlennen, MD

Tools for the Dental Professional: Testing for SARS-CoV-2 In response to the pandemic, the community of laboratories from across the globe have worked to develop new tests to diagnose COVID-19 and to identify persons who have successfully survived the infection. There are then 2 types of tests for these two conditions. To diagnose COVID-19 a sample of nasal or oral secretions are collected to look for viral RNA, evidence of the presence of SARS-CoV-2 in that person. In short, laborat...

COVID-19: A Primer for the Dental Professional Part 1

Posted on May 29, 2020May 28, 2020 by Ronald C. McGlennen, MD

The pandemic caused by the virus, SARS-CoV-2, has descended upon us with a speed and seriousness unprecedented in our modern history. The virus causing the disease called COVID-19 has been revealed to be both stealthy as well as terribly dramatic. The virus and the disease have taken not only the health and lives of many in our country, but also, in the effort to stem the pandemic, our economy as well. As we look forward to an ebb in the number of newly afflicted persons, it is important to ...

Drug Allergy vs. Drug Intolerance

Posted on January 11, 2019August 30, 2019 by Ronald C. McGlennen, MD

A mark of a great diagnostician is one who can avoid complications through a process of taking an expert medical history. One area of practice where taking a history is critical, if not life saving, is documenting the potential of side effects from prescribed medications, in particular antibiotics. Patients are quick to state, “I’m allergic to that medication”. But what do they mean by that? Allergies are not the same as drug sensitivity or intolerance, and the earnest clinician needs to fig...

Where Does the HPV Go?

Posted on April 27, 2018August 30, 2019 by Ronald C. McGlennen, MD

The alarming incidence of oral cancer connected to oral infections caused by the human papillomavirus, HPV, should rightly raise concern. For too long healthcare has overlooked the potential of HPV to cause serious disease in the oral cavity, the pharynx and larynx. Fortunately, early detection is key, and there is now a highly sensitive test that can identify early HPV infections called OraRisk ® HPV. OraRisk ® HPV identifies the HPV infection often before any clinical symptoms can be se...

What is “Differential Diagnosis”?

Posted on December 15, 2017August 30, 2019 by Ronald C. McGlennen, MD

There is an old adage in medicine that says “When you hear hoof beats, think horses. Don’t think zebras.” This phrase can be applied to every patient and case; your eyes don’t tell the whole story. It is usually good advice to confirm the obvious, rather than spending time and resources investigating rare things. Consider the virtue of the “differential diagnosis”. In medicine, the differential diagnosis is a process by which the consideration of diagnosing one disease is distinguished fr...

Connecting the Dots: A Role for Inflammation in Oral and Pharyngeal Cancers

Posted on September 1, 2017August 30, 2019 by Ronald C. McGlennen, MD

September is sexual health awareness month. In recognition, enjoy a previous post by Dr McGlennen regarding oral health and sexual health. It is important to understand the role of human papillomavirus (HPV) in the development of squamous cancers of the head and neck. But it seems there is missing a fuller appreciation of other key risk factors at work with the virus, to cause bad things to happen to cells in the mouth and throat. HPV infection is very common, and with the sensitive molecular...

Pharmacogenetics: Many medicines work differently on different people, Why?

Posted on June 2, 2017August 30, 2019 by Ronald C. McGlennen, MD

Insights into the structure of the human genome have taught us much about the genetic basis of disease. But what about the genetic nature of health and more specifically, how we as individuals deal with medication? We are, as a species, 99.5% genetically the same. But that last 0.5% difference serves to explain the wide diversity we experience as people in general, including why some respond to medications, and others not as well, or not at all. Here is an example. People who suffer from ...