The Oral–Gut–Cancer Connection: Why the Mouth Is a Gateway to Systemic Health

Posted on April 10, 2026April 9, 2026 by Tabatha Pittman, PA-C

Emerging research confirms that the oral cavity is not biologically isolated from the rest of the body. The mouth serves as a primary gateway to the gastrointestinal tract and immune system, continuously introducing microbes, inflammatory signals, and immune-modulating compounds into systemic circulation. Each day, approximately 1–1.5 liters of saliva containing oral bacteria is swallowed, creating a direct microbial bridge between the oral microbiome and gut microbiome. This oral–gut axi...

An Imbalanced Oral Microbiome Can Cause Throat Cancer, But You Can Prevent It

Posted on June 13, 2025May 29, 2025 by Cass Nelson-Dooley MS

Every April, there is a campaign to bring awareness to head and neck cancers. What exactly are head and neck cancers? Head and neck cancers affect the mouth, throat, sinuses and nose, salivary glands, or larynx (the voice box). Their hallmark is that they involve squamous cells, which line the mouth, throat, and sinuses—those wet, mucous-rich surfaces. How do head and neck cancers take hold? Cancer cells are damaged cells that can live forever. Cancer requires one or more of these proce...

Throwback: Side Effects Support LLC

Posted on May 23, 2025May 15, 2025 by Jill Meyer-Lippert RDH

As I started my first job in dentistry, my mother received a breast cancer diagnosis and suffered horribly with oral side effects from chemotherapy. Her pain from severe dry mouth and mouth sores (oral mucositis) was dismissed by her oncology team as “just part of treatments.” She received no guidance on how to prevent or reduce her discomfort and there were no oral care strategies implemented to prevent long-term damage to her dental health. Through questioning other cancer survivors, I le...

Protect Patient Health with Salivary Diagnostics

Posted on April 4, 2025April 18, 2025 by Kathryn Gilliam

Persistent oral human papillomavirus (HPV) infections have been linked to an increased risk of oral and oropharyngeal cancer. According to the Center for Disease Control and Prevention (CDC), HPV is the most common sexually transmitted infection. Over 200 strains of HPV have been identified. The high-risk types, HPV-16 and HPV-18 are associated with oropharyngeal squamous cell carcinoma (OPSCC). The CDC reports that HPV is responsible for approximately 70% of oropharyngeal cancer in the Unit...

Research Spotlight: Oral Squamous Cell Carcinoma and the Role of Salivary Diagnostics by Emily Long, BS

Posted on November 15, 2024January 23, 2025 by Emily Long

Oral squamous cell carcinoma (OSCC) accounts for 90% of all head and neck cancers, posing a significant public health concern worldwide (Shafiq et al., 2023). Despite increasing awareness, OSCC is frequently diagnosed at advanced stages, leading to poor prognoses and lower survival rates (Roi et al., 2019). If untreated, this type of cancer can metastasize, spreading to other regions of the body. According to the National Cancer Institute, 53% of cancers in the oral cavity and pharynx are id...

Part 2: Build the Microscopic Army in Your Mouth to Fight Oral Cancer and Improve Dental Health

Posted on May 7, 2021May 20, 2021 by Cass Nelson-Dooley MS

Last week in part 1, oral cancer was defined with a potential cause being oral dysbiosis identified. This week, I will give supporting evidence of this connection along with strategies to avoid this dysbiosis. When we talk about an unhealthy microbiome, we often use the word, “dysbiosis.” Oral dysbiosis is a mouth that is unhealthy because the microorganisms are out of balance. An imbalanced microbiome may lead to symptoms or disease. Symptoms of Oral Dysbiosis: Bad breath Blee...

Part 1: Build the Microscopic Army in Your Mouth to Fight Oral Cancer and Improve Dental Health

Posted on April 30, 2021April 30, 2021 by Cass Nelson-Dooley MS

Oral Cancer Is No Match for a Healthy Oral Microbiome Fostering a healthy oral microbiome can fight oral and other cancers. That’s nothing to say for its benefits on cavities, root canal infections, and gum disease. Your friendly bacteria protect you from disease, fight tumors, cool off inflammation, and boost your immune system. Who wouldn’t want this army of microscopic warriors on their side?! In this two-part blog, you will learn that cancers can be caused by bacteria, viruses, ...

Side Effects Support LLC

Posted on April 17, 2020May 20, 2021 by Jill Meyer-Lippert RDH

Relapsed Periodontal Maintenance Patient with Breast Cancer

Posted on November 15, 2019May 20, 2021 by Maria Teague RDH

Challenge: A periodontal maintenance patient of record presented past due for recare. The initial exam revealed signs of active periodontal disease indicating that the patient is no longer in periodontal remission. Medically, the patient is undergoing treatment for breast cancer. Background: A 54-year-old female patient of record, with history of successful periodontal therapy, has relapsed due to missed recare and decreased oral home care. A diagnosis of breast cancer in Spring 2019 has ...

How do you speak Risk of Cancer and Periodontal Disease with your patients?

Posted on September 6, 2019August 14, 2024 by Michael C. Rogers, DDS

Dr McGlennen: Cancer is a word that receives a lot of attention. There are walks, runs and bike rides every day to raise awareness of various types of cancers and billions of dollars are spent on research directed to improve diagnosis and treatments. As health care professionals, we should perform a cancer risk assessment for each patient with a goal to reduce the patient’s risk and to find cancers earlier when cure is more likely. One way that the dental office can contr...